Metoclopramide
Introduction :
Generic Name :
Metoclopramide
Brand Names :
Reglan
Availability :
Injection : 5mg/ml
Syrup : 5mg/ml
Tablets : 5mg, 10mg
Classification :
Antiemetics
Action :
- Stimulates motility of upper G.I tract,
- Increases lower esophageal sphincter tone.
- Blocks dopamine receptors at the chemoreceptor trigger zone.
Indication :
Emesis during pregnancy
Dosage :
Adults : 5 - 10mg
Contra Indication :
- Contraindicated to patients hypersensitive to drug and in those with phechromocytoma or seizure disorders.
- Contraindicated in patients for whom stimulation on of G.I motility might be dangerous ( those with hemorrhage, obstruction, or perforation.
- Use cautiously in patients with history of depression, parkinson's disease or hypertesion.
Adverse Effects :
CNS :
Restlessness,
anxiety, drowsiness, fatigue, lassitude, fever, depression, akathisia, insomnia
confusion, suicide i ideation, seizures, neuroletic malignant syndrome,
hallucinations, headache, dizziness.
transient
hypertension,
Hypertension
on superaventricular tachycardia, bradycardia.
nausea,
bowel disorders, diarrhea.
Urinary
frequency, incontinence.
neutroenia.
Rash,
urticaria.
Prolactin
secretion,
Loss
of libido.
Nursing Responsibility / Intervention :
- Monitor bowel sounds.
- safety and effectiveness of drug haven't been established for therapy lasting longer than 12 weeks.
- when oral solution is used ( 10mg/ml) dilute in pudding, applesauce, juice, or water just before using.
- Alert : Use diphenhydramine 25mg IV.
