FRUSEMIDE
CLASSIFICATION : DIURETICS
TRADE NAME : LASIX
GENERIC NAME : FRUSEMIDE
- It is a strong diuretic but lacks specific anti-hypertensive action. ( has no direct effect on resistance vessels).
- Thus anti hypertensive efficacy is directly related to diuretic potency.
- Fall in BP is due only to reduced plasma extracellular fluid volume.
Indications :
- Oedema in congestive heart failure,
- hepatic and renal disease.
- Cerebral oedema,
- forced diuresis for poisoning,
- toxaemia of pregnancy.
- Hypertension and hypertensive crisis.
- Pulmonary edema
Dosage :
- ADULT : 20-80 mg as a single dose. if satisfactory results are not obtained than 20-40 mg after 6 hrs. INFANT & CHILDREN : 2mg /kg body wt increased by 1-2 mg/kg 6-8 hrs after the previous dose. MAX : 40 mg /day.
CONTRA INDICATIONS :
- Renal failure with anuria,
- potassium deficiency ( i.e. malnutrition, diarrhoea).
- Hypersensitivity to frusemide & sulphonamides,
- Hypokalaemia
- Hyponatraemia
- Hepatic coma
- Hypovolaemia with/without hypotension.
- Electrolyte imbalance (monitor serum electrolyte)
- Paediatrics : can be used safely.
- Pregnancy : Contraindicated.
- Lactation : Used if clearly indicated.
- Elderly : Increased risk of side effects. Dose to be reduced.
- Vertigo.
- Visual impairment.
- Sodium deficiency may cause orthostatic hypotension.
- Calf muscle cramps.
- Anorexia.
- Weakness.
- Dizzinesss.
- Drowsiness.
- Vomiting.
- hyperuricaemia reduced glucose tolerance.
- Deafness.
- Aminoglycoside antibiotics may enhance the risk of deafness, potentiates anti hypertensives, causes litihum toxicity in those receiving both drugs. With cotrimoxazole produces thrombocytopenia. NSAIDs diminish the diuretic effects.
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