Metoclopramide

Metoclopramide

Introduction :

Generic Name :

Metoclopramide

Brand Names : 

Reglan

Availability :

Injection : 5mg/ml
Syrup      : 5mg/ml
Tablets    : 5mg, 10mg

Classification :

Antiemetics

Action :

• Stimulates motility of upper G.I tract,
• Increases lower esophageal sphincter tone.
• Blocks dopamine receptors at the chemoreceptor trigger zone.

Indication :

Emesis during pregnancy

Dosage : 

Adults : 5 - 10mg

Contra Indication :

• Contraindicated to patients hypersensitive to drug and in those with phechromocytoma or seizure disorders.
• Contraindicated in patients for whom stimulation on of G.I motility might be dangerous ( those with hemorrhage, obstruction, or perforation.
• Use cautiously in patients with history of depression, parkinson's disease or hypertesion.

Adverse Effects  :

CNS :

Restlessness, anxiety, drowsiness, fatigue, lassitude, fever, depression, akathisia, insomnia confusion, suicide i ideation, seizures, neuroletic malignant syndrome, hallucinations, headache, dizziness.

CV :

transient hypertension,

Hypertension on superaventricular tachycardia, bradycardia.

GI :

nausea, bowel disorders, diarrhea.

GU :

Urinary frequency, incontinence.

Hematologic :

neutroenia.

Skin :

Rash, urticaria.

Other :

Prolactin secretion,

Loss of libido.

Nursing Responsibility / Intervention  :

• Monitor bowel sounds.
• safety and effectiveness of drug haven't been established for therapy lasting longer than 12 weeks.
• when oral solution is used ( 10mg/ml) dilute in pudding, applesauce, juice, or water just before using.
• Alert : Use diphenhydramine 25mg IV.

 Images : 

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