FRUSEMIDE (LASIX)

FRUSEMIDE 

CLASSIFICATION   :    DIURETICS

TRADE NAME          :    LASIX 

GENERIC NAME      :    FRUSEMIDE

• It is a strong diuretic but lacks specific anti-hypertensive action. ( has no direct effect on resistance vessels). 
• Thus anti hypertensive efficacy is directly related to diuretic potency. 
• Fall in BP is due only to reduced plasma extracellular fluid volume.

Indications :

• Oedema in congestive heart failure,
• hepatic and renal disease. 
• Cerebral oedema, 
• forced diuresis for poisoning, 
• toxaemia of pregnancy.
•  Hypertension and hypertensive crisis.
• Pulmonary edema

  Dosage : 

•  ADULT : 20-80 mg as a single dose. if satisfactory results are not obtained than 20-40 mg after 6 hrs.  INFANT & CHILDREN : 2mg /kg body wt increased by 1-2 mg/kg 6-8 hrs after the previous dose.  MAX : 40 mg /day.

CONTRA INDICATIONS :

• Renal failure with anuria,
• potassium deficiency ( i.e. malnutrition, diarrhoea).
• Hypersensitivity to frusemide & sulphonamides,
• Hypokalaemia 
• Hyponatraemia
• Hepatic coma
• Hypovolaemia with/without hypotension.

SPECIAL PRECAUTIONS :

• Electrolyte imbalance (monitor serum electrolyte)
• Paediatrics : can be used safely.
• Pregnancy : Contraindicated.
• Lactation : Used if clearly indicated.
• Elderly : Increased risk of side effects. Dose to be reduced.

SIDE EFFECTS :

• Vertigo.
• Visual impairment.
• Sodium deficiency may cause orthostatic hypotension.
• Calf muscle cramps.
• Anorexia.
• Weakness.
• Dizzinesss.
• Drowsiness.
• Vomiting.
• hyperuricaemia reduced glucose tolerance.
• Deafness.

DRUG INTERACTIONS :

•  Aminoglycoside  antibiotics may enhance the risk of deafness, potentiates anti hypertensives, causes litihum toxicity in those receiving both drugs. With cotrimoxazole produces thrombocytopenia. NSAIDs diminish the diuretic effects. 

 

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